FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Integrin β4
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
修饰-Modification
Unmodified
MW(Calculated)
202kD
MW(Observed)
210kD
推荐稀释比
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
Monoclonal
免疫原
PT1416R
特异性
Endogenous
基因名称
ITGB4
蛋白名称
Integrin beta-4
别名
ITGB4;Integrin beta-4;GP150;CD antigen CD104
Organism-1
Human
基因ID-1
3691
SwissProt-1
P16144
Organism-2
Mouse
SwissProt-2
A2A863
Organism-3
Rat
基因ID-3
25724
SwissProt-3
Q64632
背景
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
