FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ABL1
反应性
Human
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
修饰-Modification
Phospho
MW(Calculated)
123kD
MW(Observed)
210kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
Monoclonal
免疫原
PT1402R
特异性
ABL1 (Phospho Tyr245) Antibody detects endogenous levels of ABL1 protein only when phosphorylated at Y245.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TVyGV
基因名称
ABL1 ABL JTK7
蛋白名称
Tyrosine-protein kinase ABL1;Proto-oncogene c-Abl;
别名
c-Abl;ABL1;ABL;JTK7;Tyrosine-protein kinase ABL1;Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;Proto-oncogene c-Abl;p150;
Organism-1
Human
基因ID-1
25
SwissProt-1
P00519
Organism-2
Mouse
基因ID-2
11350
SwissProt-2
P00520
Organism-3
Rat
基因ID-3
311860
背景
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr
细胞定位
Cytoplasm > cytoskeleton. Nucleus. Sequestered into the cytoplasm through interaction with 14-3-3 proteins and Nucleus membrane. The myristoylated c-ABL protein is reported to be nuclear.
