FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Claudin 11
反应性
Human,Mouse,Rat
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
修饰-Modification
Unmodified
MW(Calculated)
22kD
MW(Observed)
22kD
推荐稀释比
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
Monoclonal
免疫原
PT1418R
特异性
Endogenous
基因名称
CLDN11
蛋白名称
Claudin-11
别名
CLDN11;OSP;OTM;Claudin-11;Oligodendrocyte-specific protein
Organism-1
Human
基因ID-1
5010
SwissProt-1
O75508
Organism-2
Mouse
基因ID-2
18417
SwissProt-2
Q60771
Organism-3
Rat
SwissProt-3
Q99P82
背景
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso
细胞定位
Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .
