FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Claudin 18.2
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
修饰-Modification
Unmodified
MW(Calculated)
28kD
MW(Observed)
28kD
推荐稀释比
IHC 1:200-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
Monoclonal
免疫原
PT1448R
特异性
Endogenous
基因名称
CLDN18 UNQ778/PRO1572
蛋白名称
Claudin-18
别名
Claudin-18
Organism-1
Human
基因ID-1
51208
SwissProt-1
P56856-2
Organism-2
Mouse
基因ID-2
56492
SwissProt-2
P56857
背景
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010],
细胞定位
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . Localizes to tight junctions in epithelial cells. .
