FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
TFE3
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
修饰-Modification
Unmodified
MW(Calculated)
62kD
MW(Observed)
72-89kD
推荐稀释比
IHC 1:100-1:500;WB 1:1000-1:20000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
Monoclonal
免疫原
PT1512R
特异性
Endogenous
基因名称
TFE3 BHLHE33
蛋白名称
Transcription factor E3
别名
TFE3;BHLHE33;Transcription factor E3;Class E basic helix-loop-helix protein 33;bHLHe33
Organism-1
Human
基因ID-1
7030
SwissProt-1
P19532
Organism-2
Mouse
基因ID-2
209446
SwissProt-2
Q64092
背景
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
细胞定位
Cytoplasm, cytosol . Nucleus . When nutrients are present, phosphorylation by MTOR prevents nuclear translocation and activity (PubMed:22692423, PubMed:30733432). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:22692423, PubMed:30733432). .
