FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Gab 1
反应性
Human
应用
WB,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
77kD
MW(Observed)
110kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1190R
特异性
Endogenous
基因名称
GAB1
蛋白名称
GRB2-associated-binding protein 1
别名
GAB1;GRB2-associated-binding protein 1;GRB2-associated binder 1;Growth factor receptor bound protein 2-associated protein 1
Organism-1
Human
基因ID-1
2549
SwissProt-1
Q13480
Organism-2
Mouse
基因ID-2
14388
SwissProt-2
Q9QYY0
背景
GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
细胞定位
Function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,
