FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
GLI-1
反应性
Human
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
118kD
MW(Observed)
160kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1049R
特异性
Endogenous
基因名称
GLI1 GLI
蛋白名称
Zinc finger protein GLI1
别名
Zinc finger protein GLI1;Glioma-associated oncogene;Oncogene GLI;
Organism-1
Human
基因ID-1
2735
SwissProt-1
P08151
Organism-2
Mouse
基因ID-2
14632
SwissProt-2
P47806
背景
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],
细胞定位
Disease:Defects in GLI1 may be a cause of breast cancer.,Function:May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.,induction:Amplified in glioblastoma cells.,similarity:Belongs to the GLI C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subcellular location:Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36.,tissue specificity:Testis, myometrium and fallopian tube.,
