FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ALPL
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
57kD
MW(Observed)
80kD
推荐稀释比
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1342R
特异性
Endogenous
基因名称
ALPL
蛋白名称
Alkaline phosphatase tissue-nonspecific isozyme
别名
ALPL;Alkaline phosphatase;tissue-nonspecific isozyme;AP-TNAP;TNSALP;Alkaline phosphatase liver/bone/kidney isozyme
Organism-1
Human
基因ID-1
249
SwissProt-1
P05186
Organism-2
Mouse
基因ID-2
11647
SwissProt-2
P09242
Organism-3
Rat
基因ID-3
25586
SwissProt-3
P08289
背景
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
细胞定位
Catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,Disease:Defects in ALPL are a cause of hypophosphatasia adult type (hypophosphatasia) [MIM:146300].,Disease:Defects in ALPL are a cause of hypophosphatasia childhood (hypophosphatasia) [MIM:241510].,Disease:Defects in ALPL are a cause of hypophosphatasia infantile (hypophosphatasia) [MIM:241500]; an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto).,Function:This isozyme may play a role in skeletal mineralization.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,online information:Tissue nonspecific alkaline phosphatase gene mutations database,PTM:Glycosylated.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer.,
