FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
NR1D1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
67kD
MW(Observed)
55kD
推荐稀释比
IHC 1:200-1:1000;WB 1:10000-1:50000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1219R
特异性
Endogenous
基因名称
NR1D1
蛋白名称
Nuclear receptor subfamily 1 group D member 1
别名
NR1D1;EAR1;HREV;THRAL;Nuclear receptor subfamily 1 group D member 1;Rev-erbA-alpha;V-erbA-related protein 1;EAR-1
Organism-1
Human
基因ID-1
9572
SwissProt-1
P20393
Organism-2
Mouse
基因ID-2
217166
SwissProt-2
Q3UV55
Organism-3
Rat
基因ID-3
252917
SwissProt-3
Q63503
背景
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013],
细胞定位
Domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,Function:Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with C1D.,tissue specificity:Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines.,
