FGF-2 Polyclonal Antibody
¥680.00
PLC γ2 (Phospho Tyr1217) Rabbit mAb
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2621935
- 产品信息
商品描述
靶点-Target
PLCG2
反应性
Human
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
148kD
MW(Observed)
150kD
推荐稀释比
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1383R
特异性
PLC γ2 (Phospho Tyr1217) Antibody detects endogenous levels of PLC γ2 protein only when phosphorylated at Y1217.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):FLyDT
基因名称
PLCG2
蛋白名称
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
别名
PLCG2;1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase gamma-2;Phosphoinositide phospholipase C-gamma-2;Phospholipase C-IV;PLC-IV;Phospholipase C-gamma-2;PLC-gamma-2
Organism-1
Human
基因ID-1
5336
SwissProt-1
P16885
Organism-2
Mouse
基因ID-2
234779
SwissProt-2
Q8CIH5
Organism-3
Rat
基因ID-3
29337
SwissProt-3
P24135
背景
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],
细胞定位
Catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,Function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,
