FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Ref-1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
36kD
MW(Observed)
36kD
推荐稀释比
IHC 1:1000-1:4000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1324R
特异性
Endogenous
基因名称
APEX1
蛋白名称
DNA-(apurinic or apyrimidinic site) lyase
别名
APEX1;APE;APE1;APEX;APX;HAP1;REF1;DNA-;apurinic or apyrimidinic site;lyase;APEX nuclease;APEN;Apurinic-apyrimidinic endonuclease 1;AP endonuclease 1;APE-1;REF-1;Redox factor-1
Organism-1
Human
基因ID-1
328
SwissProt-1
P27695
Organism-2
Mouse
基因ID-2
11792
SwissProt-2
P28352
Organism-3
Rat
基因ID-3
79116
SwissProt-3
P43138
背景
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008],
细胞定位
Catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,Function:Repairs oxidative DNA damages in vitro. May have a role in protection against cell lethality and suppression of mutations. Removes the blocking groups from the 3'-termini of the DNA strand breaks generated by ionizing radiations and bleomycin.,similarity:Belongs to the DNA repair enzymes AP/exoA family.,subunit:Monomer. Component of the SET complex, which also contains SET, ANP32A, HMGB2 and NME1.,
