FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ETAR
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
49kD
MW(Observed)
65kD
推荐稀释比
IHC 1:200-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1210R
特异性
Endogenous
基因名称
EDNRA
蛋白名称
Endothelin-1 receptor
别名
EDNRA;ETA;ETRA;Endothelin-1 receptor;Endothelin A receptor;ET-A;ETA-R;hET-AR
Organism-1
Human
基因ID-1
1909
SwissProt-1
P25101
Organism-2
Mouse
基因ID-2
13617
SwissProt-2
Q61614
背景
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
细胞定位
Function:Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with HDAC7 and HTATIP.,tissue specificity:Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.,
