FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Progranulin
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
64kD
MW(Observed)
88kD
推荐稀释比
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1318R
特异性
Endogenous
基因名称
GRN
蛋白名称
Progranulin
别名
Granulins;Proepithelin;PEPI;[Cleaved into: Acrogranin;Paragranulin;Granulin-1;Granulin G;Granulin-2;Granulin F;Granulin-3;Granulin B;Granulin-4;Granulin A;Granulin-5;Granulin C;Granulin-6;Granulin D;Granulin-7;Granulin E;]
Organism-1
Human
基因ID-1
2896
SwissProt-1
P28799
Organism-2
Mouse
SwissProt-2
P28798
Organism-3
Rat
基因ID-3
29143
SwissProt-3
P23785
背景
disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.,function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.,function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.,PTM:Granulins are disulfide bridged.,similarity:Belongs to the granulin family.,tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.,
细胞定位
in utero embryonic development, blastocyst development, blastocyst hatching, female pregnancy, embryo implantation, positive regulation of cell proliferation, embryonic development ending in birth or egg hatching, hatching,regulation of cell proliferation, chordate embryonic development, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation,
