FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Mnk1
反应性
Human,Mouse
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
51kD
MW(Observed)
51kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1363R
特异性
Endogenous
基因名称
MKNK1
蛋白名称
MAP kinase-interacting serine/threonine-protein kinase 1
别名
MKNK1;MNK1;MAP kinase-interacting serine/threonine-protein kinase 1;MAP kinase signal-integrating kinase 1;MAPK signal-integrating kinase 1;Mnk1
Organism-1
Human
基因ID-1
8569
SwissProt-1
Q9BUB5
Organism-2
Mouse
基因ID-2
17346
SwissProt-2
O08605
Organism-3
Rat
基因ID-3
500526
SwissProt-3
Q4G050
背景
MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],
细胞定位
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.,Function:May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.,PTM:Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.,tissue specificity:Ubiquitous.,
