FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
UBF-1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
MW(Calculated)
89kD
MW(Observed)
89kD
推荐稀释比
IHC 1:400-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1341R
特异性
Endogenous
基因名称
UBTF
蛋白名称
Nucleolar transcription factor 1
别名
UBTF;UBF;UBF1;Nucleolar transcription factor 1;Autoantigen NOR-90;Upstream-binding factor 1;UBF-1
Organism-1
Human
基因ID-1
7343
SwissProt-1
P17480
Organism-2
Mouse
SwissProt-2
P25976
Organism-3
Rat
基因ID-3
25574
SwissProt-3
P25977
背景
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011],
细胞定位
Function:Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element.,PTM:Phosphorylated and activated by PIK3CA.,similarity:Contains 6 HMG box DNA-binding domains.,subunit:Homodimer. Binds to IRS1 and PIK3CA.,
