- 产品信息
商品描述
靶点-Target
NF-L
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
62kD
MW(Observed)
68kD
推荐稀释比
IHC 1:2000-1:10000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1146R
特异性
Endogenous
基因名称
NEFL NF68 NFL
蛋白名称
Neurofilament light polypeptide;NF-L;Neurofilament triplet L protein;68 kDa neurofilament protein;
别名
Neurofilament light polypeptide;NF-L;68 kDa neurofilament protein;Neurofilament triplet L protein;
Organism-1
Human
基因ID-1
4747
SwissProt-1
P07196
Organism-2
Mouse
基因ID-2
18039
SwissProt-2
P08551
Organism-3
Rat
基因ID-3
83613
SwissProt-3
P19527
背景
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],
细胞定位
Cytoplasmic





