FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MRE11
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
81kD
MW(Observed)
81kD
推荐稀释比
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT1041R
特异性
Endogenous
基因名称
MRE11A HNGS1 MRE11
蛋白名称
Double-strand break repair protein MRE11A
别名
MRE11A;HNGS1;MRE11;Double-strand break repair protein MRE11A;Meiotic recombination 11 homolog 1;MRE11 homolog 1;Meiotic recombination 11 homolog A;MRE11 homolog A
Organism-1
Human
基因ID-1
4361
SwissProt-1
P49959
Organism-2
Mouse
基因ID-2
17535
SwissProt-2
Q61216
Organism-3
Rat
基因ID-3
64046
SwissProt-3
Q9JIM0
背景
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents. .
