FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
BRAT1
反应性
Human
应用
WB,FC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
90kDa
MW(Observed)
90kDa
推荐稀释比
WB 1:1000-1:5000;FC 1:100-1:500;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
PT1113R
特异性
Endogenous
基因名称
BRAT1;BAAT1;C7orf27
蛋白名称
BRCA1-associated ATM activator 1;BRCA1-associated protein required for ATM activation protein 1;
别名
BRAT1;BAAT1;C7orf27;BRCA1-associated ATM activator 1 ;BRCA1-associated protein required for ATM activation protein 1;
Organism-1
Human
基因ID-1
221927
SwissProt-1
Q6PJG6
背景
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]
细胞定位
Nucleus. Cytoplasm. Note=Present at double strand breaks (DSBs)following ionizing radiation treatment. The ubiquitinated form localizes in the nucleus in a NDFIP1-dependent manner..
