FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CUL4A/B
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
88104kD
MW(Observed)
88104kD
推荐稀释比
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
PT0950R
特异性
Endogenous
基因名称
CUL4A/CUL4B
蛋白名称
Cullin-4A (CUL-4A)/Cullin-4B
别名
CUL4B;KIAA0695;Cullin-4B;CUL-4B
Organism-1
Human
基因ID-1
8451;8450
SwissProt-1
Q13619;Q13620
Organism-2
Mouse
SwissProt-2
Q3TCH7,A2A432
背景
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009],CUL4B is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus .Cytoplasm.
