FGF-2 Polyclonal Antibody
¥680.00
PLCγ1 (Phospho Tyr783) Rabbit mAb
活动价：
¥1680.00
市场价：¥2400.00
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产品规格：
- 100ul
货号：
FAB2621673
- 产品信息
商品描述
靶点-Target
PLCG1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG, Kappa
偶联-Conjugate
Phospho
修饰-Modification
Tyr783
MW(Calculated)
149kD
MW(Observed)
149kD
推荐稀释比
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
PT0758R
特异性
PLCγ1 (Phospho Tyr783) Monoclonal Antibody detects endogenous levels of PLC γ1 protein only when phosphorylated at Y783.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GFyVE
基因名称
PLCG1
蛋白名称
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
别名
PLCG1;PLC1;1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase gamma-1;PLC-148;Phosphoinositide phospholipase C-gamma-1;Phospholipase C-II;PLC-II;Phospholipase C-gamma-1;PLC-gamma-1
Organism-1
Human
基因ID-1
5335
SwissProt-1
P19174
Organism-2
Mouse
基因ID-2
18803
SwissProt-2
Q62077
Organism-3
Rat
基因ID-3
25738
SwissProt-3
P10686
背景
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cell projection, lamellipodium . Cell projection, ruffle . Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. .
