FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Atm
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Phospho
修饰-Modification
Ser1981
MW(Calculated)
351kD
MW(Observed)
351kD
推荐稀释比
IHC 1:200-1:1000;WB 1:10000-1:50000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
PT0902R
特异性
ATM (Phospho Ser1981) Monoclonal Antibody detects endogenous levels of Phospho Atm around the phosphorylation site of S1981(human), S1896(mouse), S1927(rat) protein.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):EGsQS
基因名称
ATM
蛋白名称
Serine-protein kinase ATM
别名
ATM;Serine-protein kinase ATM;Ataxia telangiectasia mutated;A-T mutated
Organism-1
Human
基因ID-1
472
SwissProt-1
Q13315
Organism-2
Mouse
基因ID-2
11920
SwissProt-2
Q62388
背景
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],
细胞定位
Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. .
