FGF-2 Polyclonal Antibody
¥680.00
PERK (Phospho Thr980) Rabbit mAb
活动价：
¥1680.00
市场价：¥2400.00
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产品规格：
- 100ul
货号：
FAB2621627
- 产品信息
商品描述
靶点-Target
PERK
反应性
Mouse,Rat
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Phospho
修饰-Modification
Thr980
MW(Calculated)
125kD
MW(Observed)
125kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆号
PT0868R
特异性
PERK (Phospho Thr980) Antibody detects endogenous levels of PERK protein only when phosphorylated at T980.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YArHT
基因名称
EIF2AK3
蛋白名称
Eukaryotic translation initiation factor 2-alpha kinase 3
别名
EIF2AK3;PEK;PERK;Eukaryotic translation initiation factor 2-alpha kinase 3;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK
Organism-1
Human
基因ID-1
9451
SwissProt-1
Q9NZJ5
Organism-2
Mouse
SwissProt-2
Q9Z2B5
Organism-3
Rat
基因ID-3
29702
SwissProt-3
Q9Z1Z1
背景
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],
细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
