FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
p14ARF
反应性
Human,
应用
WB,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
14kD
MW(Observed)
16kD
推荐稀释比
WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0332R
特异性
Endogenous
基因名称
CDKN2A
蛋白名称
Cyclin-dependent kinase inhibitor 2A isoform 4
别名
CDKN2A;CDKN2;MLM;Cyclin-dependent kinase inhibitor 2A;isoform 4;p14ARF;p19ARF
Organism-1
Human
基因ID-1
1029
SwissProt-1
Q8N726
Organism-2
Mouse
SwissProt-2
Q64364
背景
CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by CDKN2A, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. CDKN2A is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
细胞定位
Nuclear
