FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Cdk6
反应性
Human,
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
37kD
MW(Observed)
37kD
推荐稀释比
IHC 1:200-1000;WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0069R
特异性
Endogenous
基因名称
CDK6 CDKN6
蛋白名称
Cyclin-dependent kinase 6 (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
别名
Cyclin-dependent kinase 6;Cell division protein kinase 6;Serine/threonine-protein kinase PLSTIRE;
Organism-1
Human
基因ID-1
1021
SwissProt-1
Q00534
Organism-2
Mouse
基因ID-2
12571
SwissProt-2
Q64261
背景
cyclin dependent kinase 6(CDK6) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefS
细胞定位
Nuclear
