FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
p27
反应性
Human,Mouse,Rat,
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
27kD
MW(Observed)
27kD
推荐稀释比
IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200,
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0324R
特异性
Endogenous
基因名称
CDKN1B
蛋白名称
Cyclin-dependent kinase inhibitor 1B
别名
CDKN1B;KIP1;Cyclin-dependent kinase inhibitor 1B;Cyclin-dependent kinase inhibitor p27;p27Kip1
Organism-1
Human
基因ID-1
1027
SwissProt-1
P46527
Organism-2
Mouse
SwissProt-2
P46414
背景
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014],
细胞定位
Nucleus
