FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Smad2
反应性
Human,Mouse,Rat,
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Phospho
修饰-Modification
Ser250
MW(Calculated)
58kD
MW(Observed)
58kD
推荐稀释比
IHC 1:100-1:500;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0058R
特异性
This antibody detects endogenous levels of Smad2 only when phosphorylated at Ser250.This antibody does not recognize phosphorylated at other sites.
基因名称
SMAD2
蛋白名称
Mothers against decapentaplegic homolog 2
别名
SMAD2;MADH2;MADR2;Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2
Organism-1
Human
基因ID-1
4087
SwissProt-1
Q15796
Organism-2
Mouse
基因ID-2
17126
SwissProt-2
Q62432
Organism-3
Rat
基因ID-3
29357
SwissProt-3
O70436
背景
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation
细胞定位
Cytoplasm, Nuclear
