FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Cdk4
反应性
Human,Mouse,Rat,
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
34kD
MW(Observed)
34kD
推荐稀释比
WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0399R
特异性
Endogenous
基因名称
CDK4
蛋白名称
Cyclin-dependent kinase 4
别名
CDK4;Cyclin-dependent kinase 4;Cell division protein kinase 4;PSK-J3
Organism-1
Human
基因ID-1
1019
SwissProt-1
P11802
Organism-2
Mouse
基因ID-2
12567
SwissProt-2
P30285
Organism-3
Rat
基因ID-3
94201
SwissProt-3
P35426
背景
cyclin dependent kinase 4(CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm, Nucleus
