FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
RAD51
反应性
Human,Mouse,Rat,
应用
WB,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
37kD
MW(Observed)
37kD
推荐稀释比
WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0083R
特异性
Endogenous
基因名称
RAD51
蛋白名称
DNA repair protein RAD51 homolog 1
别名
RAD51;RAD51A;RECA;DNA repair protein RAD51 homolog 1;HsRAD51;hRAD51;RAD51 homolog A
Organism-1
Human
基因ID-1
5888
SwissProt-1
Q06609
Organism-2
Mouse
基因ID-2
19361
SwissProt-2
Q08297
背景
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009],
细胞定位
Cytoplasm, Nucleus
