FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PKA
反应性
Human,Mouse,Rat,
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
40kD
MW(Observed)
40kD
推荐稀释比
IHC 1:2000-1:10000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0438R
特异性
Endogenous
基因名称
PRKACA
蛋白名称
cAMP-dependent protein kinase catalytic subunit alpha
别名
PRKACA;PKACA;cAMP-dependent protein kinase catalytic subunit alpha;PKA C-alpha
Organism-1
Human
基因ID-1
5566
SwissProt-1
P17612
Organism-2
Mouse
基因ID-2
18747
SwissProt-2
P05132
Organism-3
Rat
SwissProt-3
P27791
背景
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern
细胞定位
Cytoplasm, Membrane
