FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
53BP1
反应性
Human,
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
214kD
MW(Observed)
450kD
推荐稀释比
WB 1:2000-1:10000;IHC 1:200-1:1000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0456R
特异性
Endogenous
基因名称
TP53BP1
蛋白名称
Tumor suppressor p53-binding protein 1
别名
TP53BP1;Tumor suppressor p53-binding protein 1;53BP1;p53-binding protein 1;p53BP1
Organism-1
Human
基因ID-1
7158
SwissProt-1
Q12888
Organism-2
Mouse
基因ID-2
27223
SwissProt-2
P70399
背景
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
细胞定位
Nucleus
