FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
LATS1
反应性
Human,Mouse,Rat,
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
127kD
MW(Observed)
140kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0609R
特异性
Endogenous
基因名称
LATS1 WARTS
蛋白名称
Serine/threonine-protein kinase LATS1 (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
别名
Serine/threonine-protein kinase LATS1;Large tumor suppressor homolog 1;WARTS protein kinase;h-warts;
Organism-1
Human
基因ID-1
9113
SwissProt-1
O95835
Organism-2
Mouse
基因ID-2
16798
SwissProt-2
Q8BYR2
背景
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen
细胞定位
Cytoplasm
