FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
F111A
反应性
Human
应用
WB,IHC,IF,ICC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Observed)
67kD
推荐稀释比
WB 1:1000-5000;IHC 1:100-300;ICC/IF 1:100-300
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0804R
特异性
Endogenous
基因名称
FAM111A;KIAA1895
蛋白名称
Serine protease FAM111A
别名
FAM111A;KIAA1895;Serine protease FAM111A;
Organism-1
Human
基因ID-1
63901
SwissProt-1
Q96PZ2
Organism-2
Mouse
基因ID-2
107373
SwissProt-2
Q9D2L9
背景
The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
细胞定位
Nucleus. Chromosome. Cytoplasm. Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites..
