FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ASC
反应性
Mouse,Rat,
应用
WB,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
22kD
MW(Observed)
22kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0530R
特异性
Endogenous
基因名称
PYCARD
蛋白名称
Apoptosis-associated speck-like protein containing a CARD
别名
PYCARD;ASC;CARD5;TMS1;Apoptosis-associated speck-like protein containing a CARD;hASC;Caspase recruitment domain-containing protein 5;PYD and CARD domain-containing protein;Target of methylation-induced silencing 1
Organism-1
Human
基因ID-1
29108
SwissProt-1
Q9ULZ3
Organism-2
Mouse
基因ID-2
66824
SwissProt-2
Q9EPB4
背景
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm, Nucleus
