FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
STAT5A/B
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Phospho
修饰-Modification
Tyr694
MW(Calculated)
91kD
MW(Observed)
105kD
推荐稀释比
IHC 1:100-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0067R
特异性
This antibody detects endogenous levels of STAT5A/B only when phosphorylated at Tyr694.This antibody does not recognize phosphorylated at other sites.
基因名称
STAT5A/STAT5B
蛋白名称
Signal transducer and activator of transcription 5A/B
别名
STAT5A;STAT5;Signal transducer and activator of transcription 5A;STAT5B;Signal transducer and activator of transcription 5B
Organism-1
Human
基因ID-1
6776;6777
SwissProt-1
P42229;P51692
Organism-2
Mouse
基因ID-2
20850;20851
Organism-3
Rat
基因ID-3
24918;25126
SwissProt-3
Q62771;P52632
背景
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been
细胞定位
Cytoplasm, Nucleus
