FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MeCP2
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
52kD
MW(Observed)
75kD
推荐稀释比
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0726R
特异性
Endogenous
基因名称
MECP2
蛋白名称
Methyl-CpG-binding protein 2
别名
Methyl-CpG-binding protein 2;MeCp-2 protein;MeCp2;
Organism-1
Human
基因ID-1
4204
SwissProt-1
P51608
Organism-2
Mouse
基因ID-2
17257
SwissProt-2
Q9Z2D6
Organism-3
Rat
基因ID-3
29386
SwissProt-3
Q00566
背景
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor
细胞定位
Nucleus
