FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Stat5B
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
90kD
MW(Observed)
90kD
推荐稀释比
IHC 1:1000-1:5000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0851R
特异性
Endogenous
基因名称
STAT5B
蛋白名称
Stat5B
别名
Signal transducer and activator of transcription 5B
Organism-1
Human
基因ID-1
6777
SwissProt-1
P51692
Organism-2
Mouse
基因ID-2
20851
SwissProt-2
P42232
Organism-3
Rat
基因ID-3
25126
SwissProt-3
P52632
背景
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provi
细胞定位
Cytoplasm, Nucleus
