FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Raf-1
反应性
Human,Mouse,Rat
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
73kD
MW(Observed)
73kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0668R
特异性
Endogenous
基因名称
RAF1
蛋白名称
RAF proto-oncogene serine/threonine-protein kinase
别名
RAF1;RAF;RAF proto-oncogene serine/threonine-protein kinase;Proto-oncogene c-RAF;cRaf;Raf-1
Organism-1
Human
基因ID-1
5894
SwissProt-1
P04049
Organism-2
Mouse
基因ID-2
110157
SwissProt-2
Q99N57
Organism-3
Rat
基因ID-3
24703
SwissProt-3
P11345
背景
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008],
细胞定位
Membrane, Cytoplasm, Nucleus
