FGF-2 Polyclonal Antibody
¥680.00
Zap-70 (Phospho Tyr319)/Syk (Phospho Tyr352) Rabbit mAb
活动价：
¥1680.00
市场价：¥2400.00
一键复制产品信息
产品规格：
- 100ul
货号：
FAB2621091
- 产品信息
商品描述
靶点-Target
ZAP-70/Syk
反应性
Human,Mouse
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Phospho
修饰-Modification
Tyr319/Tyr352
MW(Calculated)
70kD
MW(Observed)
70kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0710R
特异性
The antibody detects endogenous ZAP-70/Syk(Phospho AE13) protein.
基因名称
ZAP70/SYK
蛋白名称
Tyrosine-protein kinase ZAP-70/Tyrosine-protein kinase SYK
别名
ZAP70;SRK;Tyrosine-protein kinase ZAP-70;70 kDa zeta-chain associated protein;Syk-related tyrosine kinase;SYK;Tyrosine-protein kinase SYK;Spleen tyrosine kinase;p72-Syk;
Organism-1
Human
基因ID-1
7535;6850
SwissProt-1
P43403;P43405
Organism-2
Mouse
基因ID-2
22637;20963
SwissProt-2
P43404;P48025
背景
ZAP70 gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],SYK gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). cytosol .
