FGF-2 Polyclonal Antibody
¥680.00
Met (Phospho Tyr1234/1235) Rabbit mAb
活动价：
¥1680.00
市场价：¥2400.00
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产品规格：
- 100ul
货号：
FAB2621072
- 产品信息
商品描述
靶点-Target
Met
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Phospho
修饰-Modification
Tyr1234/1235
MW(Calculated)
155kD
MW(Observed)
155kD
推荐稀释比
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0745R
特异性
This antibody detects endogenous levels of Met only when phosphorylated at Tyr1234 or Thr1235,and dually phosphorylated at two sites.
基因名称
MET
蛋白名称
Met (Tyr1234/1235)
别名
Hepatocyte growth factor receptor;HGF receptor;HGF/SF receptor;Proto-oncogene c-Met;Scatter factor receptor;SF receptor;Tyrosine-protein kinase Met;
Organism-1
Human
基因ID-1
4233
SwissProt-1
P08581
Organism-2
Mouse
SwissProt-2
P16056
Organism-3
Rat
基因ID-3
24553
SwissProt-3
P97523
背景
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016],
细胞定位
Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
