FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Doublecortin
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Unmodified
MW(Calculated)
41kD
MW(Observed)
41kD
推荐稀释比
IHC 1:50-1:200;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0871R
特异性
Endogenous
基因名称
DCX
蛋白名称
Neuronal migration protein doublecortin
别名
DCX;DBCN;LISX;Neuronal migration protein doublecortin;Doublin;Lissencephalin-X;Lis-X
Organism-1
Human
基因ID-1
1641
SwissProt-1
O43602
Organism-2
Mouse
基因ID-2
13193
SwissProt-2
O88809
Organism-3
Rat
SwissProt-3
Q9ESI7
背景
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo
细胞定位
Cytoplasm . Cell projection, neuron projection . Localizes at neurite tips. .
