FGF-2 Polyclonal Antibody
¥680.00
IGF1R (Phospho Tyr1135/1136)/Insulin Receptor β (Phospho Tyr1150/1151) Rabbit mAb
活动价：
¥1680.00
市场价：¥2400.00
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产品规格：
- 100ul
货号：
FAB2620987
- 产品信息
商品描述
靶点-Target
IGF IR
反应性
Human,Mouse,Rat
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG,Kappa
偶联-Conjugate
Phospho
修饰-Modification
Tyr1135/1136/Tyr1150/1151
MW(Calculated)
156kD
MW(Observed)
95kD
推荐稀释比
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
克隆号
PT0867R
特异性
Antibody detects endogenous levels of IGF-I receptor and insulin receptor only when phosphorylated at tyrosine 1135/1136 or tyrosine 1150/1151, respectively. The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites): MAyLN
基因名称
IGF1R
蛋白名称
Insulin-like growth factor 1 receptor
别名
IGF1R;Insulin-like growth factor 1 receptor;Insulin-like growth factor I receptor;IGF-I receptor;CD antigen CD221;INSR;Insulin receptor;IR;CD antigen CD220
Organism-1
Human
基因ID-1
3480;3643
SwissProt-1
P06213;P08069
Organism-2
Mouse
基因ID-2
16001;16337
Organism-3
Rat
基因ID-3
25718
SwissProt-3
P24062;P15127
背景
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],
细胞定位
Cell membrane ; Single-pass type I membrane protein .
