FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
STAT5A/B
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
87kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human STAT5A/B
特异性
This antibody detects endogenous levels of STAT5A/B at Human, Mouse,Rat
基因名称
STAT5A STAT5
蛋白名称
STAT5A/B
别名
Signal transducer and activator of transcription 5A
Organism-1
Human
基因ID-1
6776
SwissProt-1
P42229
Organism-3
Rat
基因ID-3
24918
SwissProt-3
Q62771
背景
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been
细胞定位
Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation.
