FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
BMPR-II
反应性
Human,Mouse,Rat,Monkey
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
114kD
推荐稀释比
WB 1:1000-2000;ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human BMPR-II
特异性
This antibody detects endogenous levels of Human,Mouse,Rat,Monkey BMPR-II
基因名称
BMPR2 PPH1
蛋白名称
BMPR-II
别名
Bone morphogenetic protein receptor type-2;BMP type-2 receptor;BMPR-2;Bone morphogenetic protein receptor type II;BMP type II receptor;BMPR-II;
Organism-1
Human
基因ID-1
659
SwissProt-1
Q13873
Organism-2
Mouse
基因ID-2
12168
SwissProt-2
O35607
背景
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disea
细胞定位
Cell membrane ; Single-pass type I membrane protein.
