FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Presenilin 2
反应性
Human,Mouse,Rat
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
49kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human Presenilin 2 AA range: 270-350
特异性
This antibody detects endogenous levels of Human,Mouse,Rat Presenilin 2
基因名称
PSEN2 AD4 PS2 PSNL2 STM2
蛋白名称
Presenilin 2
别名
Presenilin-2;PS-2;AD3LP;AD5;E5-1;STM-2;[Cleaved into: Presenilin-2 NTF subunit;Presenilin-2 CTF subunit]
Organism-1
Human
基因ID-1
5664
SwissProt-1
P49810
Organism-2
Mouse
基因ID-2
19165
SwissProt-2
Q61144
Organism-3
Rat
基因ID-3
81751
SwissProt-3
O88777
背景
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008],
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .
