FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CLCN3
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
90kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human CLCN3 AA range: 597-647
特异性
This antibody detects endogenous levels of CLCN3 at Human/Mouse/Rat
基因名称
CLCN3
蛋白名称
CLCN3
Organism-1
Human
基因ID-1
1182
SwissProt-1
P51790
Organism-2
Mouse
基因ID-2
12725
SwissProt-2
P51791
Organism-3
Rat
基因ID-3
84360
SwissProt-3
P51792
背景
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
细胞定位
[Isoform 1]: Early endosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Isoform 1 is localized mainly in late endosomes. .; [Isoform 2]: Golgi apparatus membrane ; Multi-pass membrane protein . Cell projection, ruffle membrane ; Multi-pass membrane protein . Isoform 2 is mainly enriched in the Golgi (PubMed:12471024). Colocalizes with SLC9A3R1/EBP50 in membrane ruffles (PubMed:11967229). .
