FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
NEDD4
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
145kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human NEDD4 AA range: 80-130
特异性
This antibody detects endogenous levels of NEDD4 at Human/Mouse/Rat
基因名称
NEDD4 KIAA0093 NEDD4-1 PIG53
蛋白名称
NEDD4
Organism-1
Human
基因ID-1
4734
SwissProt-1
P46934
Organism-2
Mouse
基因ID-2
17999
SwissProt-2
P46935
Organism-3
Rat
基因ID-3
25489
SwissProt-3
Q62940
背景
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016],
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1. .
