FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
RASF5
反应性
Human,Mouse,Rat
应用
WB,IF,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
46kD
推荐稀释比
WB 1:500-2000;IF/ICC1:50-200;ELISA 1:2000-20000;IHC 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human RASF5 AA range: 234-284
特异性
This antibody detects endogenous levels of RASF5 at Human/Mouse/Rat
基因名称
RASSF5 NORE1 RAPL
蛋白名称
RASF5
Organism-1
Human
基因ID-1
83593
SwissProt-1
Q8WWW0
Organism-2
Mouse
基因ID-2
54354
SwissProt-2
Q5EBH1
Organism-3
Rat
基因ID-3
54355
SwissProt-3
O35141
背景
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
