FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
DEN1B
反应性
Human,Mouse
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
47kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human DEN1B AA range: 325-375
特异性
This antibody detects endogenous levels of DEN1B at Human/Mouse
基因名称
DENND1B C1orf218 FAM31B
蛋白名称
DEN1B
Organism-1
Human
基因ID-1
163486
SwissProt-1
Q6P3S1
Organism-2
Mouse
基因ID-2
329260
SwissProt-2
Q3U1T9
背景
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],
细胞定位
Cytoplasm, cytosol . Cytoplasmic vesicle, clathrin-coated vesicle .
