FGF-2 Polyclonal Antibody
¥680.00
CD66a/b/c Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2617708
- 产品信息
商品描述
靶点-Target
CD66a/b/c
反应性
Human,Rat,Mouse,
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
推荐稀释比
IHC 1:50-200;ELISA 1:10000-20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthetic peptide from human protein at AA range: 130-190
特异性
The antibody detects endogenous CD66a/b/c
基因名称
CEACAM1/CEACAM6/CEACAM8
蛋白名称
Carcinoembryonic antigen-related cell adhesion molecule 1/6/8 (CD antigen CD66a/b/c)
Organism-1
Human
基因ID-1
634;4680;1088
SwissProt-1
P13688;P40199;P31997
背景
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue thre
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Lateral cell membrane . Apical cell membrane . Basal cell membrane . Cell junction . Cell junction, adherens junction . Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes. .; [Isoform 2]: Secreted .; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .; [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; [Isoform 6]: Cell membrane; Single-pass type I membrane protein.; [Isoform 7]: Cell membrane; Single-pass type I membrane protein.; [Isoform 8]: Cell membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, secretory vesicle membrane . Lateral cell membrane . Apical cell membrane . Basal cell membrane . Cell junction . Cell junction, adherens junction . Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961). .; Cell projection, microvillus membrane ; Single-pass type I membrane protein . Apical cell membrane ; Single-pass type I membrane protein . Localized to the apical glycocalyx surface (PubMed:10436421). Colocalizes with CEACAM20 at the apical brush border of intestinal cells. .
