FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Noggin
反应性
Human,Mouse,Rat
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
推荐稀释比
IHC 1:50-200;ELISA 1:10000-20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human NOG. AA range:21-70
特异性
The antibody detects endogenous Noggin
基因名称
NOG
蛋白名称
Noggin
别名
Noggin
Organism-1
Human
基因ID-1
9241
SwissProt-1
Q13253
Organism-2
Mouse
基因ID-2
18121
SwissProt-2
P97466
Organism-3
Rat
SwissProt-3
Q62809
背景
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and mu
细胞定位
Secreted.
